{
  "@context": "https://schema.org",
  "@type": "Dataset",
  "name": "md_pereligyn protocol Patient Outcomes (Aggregated)",
  "description": "Aggregated patient outcome data from the md_pereligyn protocol for type 2 diabetes remission. Includes remission rates, HbA1c reduction, weight loss, medication discontinuation, and metabolic improvements across 500+ patients over 15 years of clinical practice.",
  "url": "https://universum.earth/datasets/outcomes-summary.json",
  "datePublished": "2026-02-08",
  "dateModified": "2026-02-08",
  "creator": {
    "@type": "Person",
    "name": "Dr. Vladimir Pereligyn",
    "url": "https://universum.earth/team",
    "jobTitle": "Creator of the md_pereligyn protocol"
  },
  "publisher": {
    "@type": "Organization",
    "name": "Universum.earth",
    "url": "https://universum.earth"
  },
  "license": "https://creativecommons.org/licenses/by-nc/4.0/",
  "temporalCoverage": "2010/2026",
  "spatialCoverage": "Global (25+ countries)",
  "variableMeasured": [
    {
      "@type": "PropertyValue",
      "name": "HbA1c",
      "unitText": "percent"
    },
    {
      "@type": "PropertyValue",
      "name": "Body Weight",
      "unitText": "kg"
    },
    {
      "@type": "PropertyValue",
      "name": "Fasting Insulin",
      "unitText": "μIU/mL"
    },
    {
      "@type": "PropertyValue",
      "name": "HOMA-IR Index"
    },
    {
      "@type": "PropertyValue",
      "name": "Remission Rate",
      "unitText": "percent"
    }
  ],
  "distribution": {
    "@type": "DataDownload",
    "encodingFormat": "application/json",
    "contentUrl": "https://universum.earth/datasets/outcomes-summary.json"
  },
  "data": {
    "sampleSize": 500,
    "studyPeriod": "2010-2026",
    "countriesServed": 25,
    "primaryOutcomes": {
      "remissionRate": 0.85,
      "remissionDefinition": "HbA1c < 6.5% maintained ≥3 months without glucose-lowering medications",
      "strictRemissionRate": 0.78,
      "strictRemissionDefinition": "HbA1c < 5.7% (normal range)",
      "meanTimeToRemissionMonths": 4.2,
      "medianTimeToRemissionMonths": 3.8
    },
    "hba1cReduction": {
      "meanBefore": 8.2,
      "meanAfter": 5.6,
      "absoluteReduction": 2.6,
      "timelineMonths": {
        "1": 7.4,
        "3": 6.3,
        "6": 5.6,
        "12": 5.5
      }
    },
    "weightLoss": {
      "meanKg": 14.2,
      "medianKg": 12.8,
      "meanDurationMonths": 6,
      "percentLosing10kgPlus": 0.72,
      "percentLosing20kgPlus": 0.28,
      "meanBmiReduction": 4.8
    },
    "medicationChanges": {
      "metforminDiscontinuation": 0.92,
      "meanMonthsToMetforminStop": 3.5,
      "sulfonylureaDiscontinuation": 0.96,
      "insulinDoseReduction50Plus": 0.85,
      "completeInsulinDiscontinuation": 0.64,
      "allMedicationFree": 0.88
    },
    "metabolicImprovements": {
      "fastingInsulin": { "before": 24.3, "after": 8.7, "unit": "μIU/mL", "changePercent": -64 },
      "homaIr": { "before": 6.8, "after": 1.9, "changePercent": -72 },
      "triglycerides": { "before": 218, "after": 112, "unit": "mg/dL", "changePercent": -49 },
      "hdlCholesterol": { "before": 38, "after": 52, "unit": "mg/dL", "changePercent": 37 },
      "alt": { "before": 42, "after": 24, "unit": "U/L", "changePercent": -43 },
      "hsCrp": { "before": 4.2, "after": 1.1, "unit": "mg/L", "changePercent": -74 },
      "systolicBp": { "before": 142, "after": 126, "unit": "mmHg", "changePercent": -11 },
      "waistCircumference": { "before": 108, "after": 94, "unit": "cm", "changePercent": -13 }
    },
    "remissionBySubgroup": {
      "prediabetes": { "rate": 0.95, "meanMonths": 2.1 },
      "diabetesUnder2years": { "rate": 0.92, "meanMonths": 2.8 },
      "diabetes2to5years": { "rate": 0.88, "meanMonths": 3.5 },
      "diabetes5to10years": { "rate": 0.80, "meanMonths": 5.2 },
      "diabetes10to15years": { "rate": 0.72, "meanMonths": 8.1 },
      "diabetes15plusYears": { "rate": 0.55, "meanMonths": 10.4 }
    },
    "longTermFollowUp": {
      "maintainingRemission6months": 0.85,
      "maintainingRemission12months": 0.82,
      "maintainingRemission24months": 0.78
    },
    "safetyProfile": {
      "seriousAdverseEvents": 0,
      "treatmentDiscontinuationDueToSideEffects": 0,
      "hypoglycemicEpisodes": 0
    }
  }
}